Everything You Need to Know About Trintellix (Vortioxetine)

#pharmacy
Video

1. Introduction and Background:

   • Trintellix (Vortioxetine) is an antidepressant medication approved in the U.S for major depressive disorder (MDD). It was renamed from Bryntillix to avoid confusion with another medication, Brelanta.
   • It has been studied for other indications like generalized anxiety disorder (GAD) but with poor evidence of effectiveness.

2. Effectiveness and Use:

   • Overall, Vortioxetine performs similarly to other antidepressants in treating MDD.
   • It may offer cognitive enhancement benefits, particularly for those with cognitive dysfunction due to depression, and has shown potential in improving cognitive function in geriatric depression. However, it didn't show benefits for Alzheimer's or ADHD.

3. Mechanism of Action:

   • Vortioxetine is a serotonin modulator and stimulator. It works by inhibiting serotonin reuptake, increasing its availability in the synaptic cleft.
   • It also modulates various serotonin receptors, with the most robust actions being on serotonin reuptake and 5-HT3 antagonism.

4. Dosage, Metabolism, and Side Effects:

   • Dosed once daily, ranging from 5 to 20 milligrams.
   • Metabolized mainly by cytochrome P450s, especially 2D6.
   • Common side effects include nausea, vomiting, constipation, sexual dysfunction, and potential weight gain. Rare side effects include seizure, mania induction, and suicidal thoughts.

5. Conclusions and Considerations:

   • Trintellix is primarily for patients with MDD, especially those with cognitive dysfunction due to their depression.
   • It has a similar side effect profile to other antidepressants, and its cost is higher than some alternatives like duloxetine.