Vitamin B3 (Nicotinamide Riboside)
- Read more here: Vitamin B3 (Niacin vs Nicotinamide vs Nicotinamide Riboside)
What is Nicotinamide Riboside?
Nicotinamide Riboside (NR), a derivative of vitamin B3, has recently gained significant attention as a forerunner in nicotinamide adenine dinucleotide (NAD+) precursor studies, attributed to its potential therapeutic utilities (1,4). As an integral part of cellular metabolism, aging, and DNA repair, NAD+ finds its precursor in NR, which is present in trace amounts in specific foods (1,3). Through a sequence of enzymatic reactions, cells can efficiently absorb NR, subsequently converting it into NAD+ (1,3). Notwithstanding its purported benefits in areas like anti-aging, cardiovascular health, neuroprotection, and energy metabolism, definitive scientific evidence remains elusive (4).
Nicotinamide Riboside: This supplement is a form of vitamin B3 that has been shown to improve glucose metabolism in the brain. It works by increasing levels of a molecule called NAD+, which is important for energy production in cells.
Uses and Benefits
- Anti-aging: Preliminary findings indicate NR's prospective role in anti-aging through the elevation of NAD+ levels (1,4,6).
- Cardiovascular health: NR has demonstrated potential in bolstering cardiovascular health by boosting NAD+ levels (1,4,6).
- Neuroprotection: NR's potential neuroprotective benefits are linked to the escalation of NAD+ levels (1,4,6).
- Energy metabolism: The augmentation of NAD+ levels by NR could be pivotal in supporting healthy energy metabolism (1,4,6).
Dosage
While a standardized dosage for NR is yet to be established, researches have administered up to 1000 mg daily (1,4). For accurate dosage guidelines, adherence to supplement label instructions or consultation with a healthcare expert is advised.
Side Effects
As a supplement, NR is typically deemed safe (4,6). However, consumption of NR in elevated doses could lead to adverse effects such as nausea, fatigue, and headaches (4). Moderation is key in its consumption.
Interactions
Data on NR's interactions with other drugs or supplements is scant. Prior to commingling NR with other supplements or medications, it's prudent to consult a healthcare specialist.
Time of Day and With or Without Food
Guidelines pertaining to the timing of NR intake or its consumption with/without food are not delineated. However, following label instructions or seeking guidance from a healthcare professional is advisable.
Human Studies
Despite extensive research on NR concerning its potential therapeutic advantages, encompassing anti-aging, cardiovascular health, neuroprotection, and energy metabolism, definitive scientific corroboration remains pending (1,4). Comprehensive research is requisite for determining its safety and efficacy in human applications.
In summation, Nicotinamide Riboside (NR), an offshoot of vitamin B3, has emerged as a significant precursor in NAD+ studies, courtesy of its potential therapeutic implications. Preliminary studies allude to its prospective benefits in anti-aging, cardiovascular well-being, neuroprotection, and energy metabolism. NR, when consumed as a supplement, is generally perceived as safe, albeit high doses might usher in certain side effects. Information on its interactions with other drugs or supplements is limited, necessitating further exhaustive research for a holistic understanding of its benefits and safety profile in humans.
Citations:
(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/
(2) https://www.differencebetween.com/difference-between-nicotinamide-and-nicotinamide-riboside/
(3) https://link.springer.com/article/10.1007/s13668-023-00475-y
(4) https://www.webmd.com/vitamins/ai/ingredientmono-1560/nicotinamide-riboside
(5) https://www.thorne.com/take-5-daily/article/meet-the-vitamin-b3-family-nr-nmn-niacin-explained
(6) https://www.geneticlifehacks.com/nad-reversing-aging-overview-of-nr-and-nmn/