Vitamin B3 (Niacin)
- Read more here: Vitamin B3 (Niacin vs Nicotinamide vs Nicotinamide Riboside)
What is Niacin?
Niacin, interchangeably referred to as vitamin B3 or nicotinic acid, is a quintessential B-complex vitamin integral to energy metabolism, DNA rectification, and cell signaling (6). It is abundantly present in various foods, notably meat, fish, and nuts (6). Niacin supplements, available in diverse forms, include the 'flush-free niacin', encompassing inositol hexanicotinate, a unique blend of six niacin molecules and a singular inositol molecule (1,2,3,5). Niacin supplements are conventionally deployed to remedy high cholesterol, ameliorate arthritis, and enhance cerebral functionality, albeit corroborative scientific evidence remains wanting (6).
Uses and Benefits
- Cardiovascular health: Niacin supplementation is reputed to curtail cholesterol levels and elevate blood fat metrics (6).
- Energy metabolism: Central to energy metabolism, Niacin is instrumental in endorsing optimal energy levels (6).
- Skin health: Studies have indicated Niacin's efficacy in enhancing dermal health and diminishing skin cancer susceptibility (6).
Dosage
The daily recommended dosage of niacin hinges on individual age and gender parameters. Men necessitate 16 mg NE daily, whereas non-pregnant or non-breastfeeding women require 14 mg NE (6). Adherence to either supplement label instructions or guidance from healthcare professionals is advocated.
Side Effects
Niacin supplementation can usher in side effects, notably flushing, pruritus, and cephalgia (1,2,3,5). An excessive intake can potentially inflict liver damage or other grave repercussions (6). It's pivotal to ensure judicious consumption.
Interactions
Niacin exhibits potential interactions with specific medications, encompassing anticoagulants, diabetic drugs, and cholesterol-alleviating medications (4). Prior to integrating Niacin supplements with other medicines, consultation with a healthcare specialist is recommended.
Time of Day and With or Without Food
There lacks a definitive guideline regarding the optimal time for niacin intake or its consumption in tandem with meals. However, adhering to label instructions on the supplement or seeking insights from healthcare professionals remains advisable.
Human Studies
While Niacin supplements have undergone evaluations for their therapeutic potential in domains like cholesterol regulation, arthritis mitigation, and cerebral enhancement, definitive scientific validation remains pending (6). Thorough research is indispensable for ascertaining the safety and efficacy of Niacin supplements in human scenarios.
To encapsulate, Niacin, colloquially termed vitamin B3 or nicotinic acid, is a pivotal B-complex vitamin that underpins energy metabolism, DNA mending, and cellular signaling. It exhibits potential in cholesterol reduction, blood fat improvement, and energy level optimization. Niacin's supplementary intake might evoke certain side effects, including flushing and headaches. Interactions with specific drugs have been observed, necessitating comprehensive research for a holistic understanding of its implications in human health.
Citations:
(1) https://www.amazon.com/Now-Supplements-Flush-Free-Niacin-Capsules/dp/B0041VJLTK
(2) https://www.target.com/p/now-foods-flush-free-niacin-500-mg-180-vegcap/-/A-88195712
(3) https://www.amazon.com/Now-Flush-Free-Niacin-250-Capsules/dp/B0013OVZ6A
(4) https://www.mayoclinic.org/drugs-supplements-niacin/art-20364984
(5) https://www.nowfoods.com/products/supplements/flush-free-niacin-250-mg-veg-capsules
(6) https://www.healthline.com/nutrition/niacin-benefits