Solriamfetol

What is Solriamfetol?

Solriamfetol is a pharmacological agent prescribed for the treatment of excessive daytime sleepiness (EDS) in adults with narcolepsy or obstructive sleep apnea/hypopnea syndrome (OSAHS). It operates as a wakefulness-promoting compound, elevating the levels of particular neurotransmitters in the brain that regulate the sleep-wake cycle (1)(2)(6).

Dosage

The standard starting dose for Solriamfetol is typically 75 mg, which may be increased to 150 mg based on clinical response and tolerability. It is intended for once-daily oral administration, with or without food (1)(3).

Side Effects

While most individuals tolerate Solriamfetol well, some may experience side effects. Commonly reported adverse effects include headaches, dizziness, insomnia, nausea, gastrointestinal disturbances, and sweating. In rare cases, serious reactions such as hypersensitivity, heart-related issues, or psychiatric symptoms could occur. Any severe side effects should prompt immediate medical consultation (1)(4)(5)(6).

Interactions

Solriamfetol can potentially interact with various other medications, which may affect its efficacy or increase the risk of adverse effects. Such interactions may be observed with monoamine oxidase inhibitors, antidepressants, and other drugs affecting the central nervous system (1)(3).

Human Studies

Clinical trials on Solriamfetol have demonstrated its effectiveness in mitigating EDS in narcolepsy and OSAHS. It has shown a comparative advantage over some other agents like modafinil and armodafinil in terms of efficacy. Research into its application for ADHD, binge eating disorder, and circadian rhythm sleep disorders is ongoing (6).

In conclusion, Solriamfetol represents an important option for managing EDS in narcolepsy and OSAHS patients. Its well-documented profile in human studies indicates it is an effective agent, although care must be taken regarding potential drug interactions and side effects. Clinical judgment and patient-specific considerations are essential when prescribing Solriamfetol.

Citations:
(1) MedlinePlus: Solriamfetol
(2) NCBI Bookshelf: Solriamfetol
(3) Drugs.com: Solriamfetol
(4) WebMD: Solriamfetol
(5) Mayo Clinic: Solriamfetol Side Effects
(6) Wikipedia: Solriamfetol