Serrapeptase
What is Serrapeptase?
Serrapeptase, also known as serratiopeptidase, is an enzyme derived from silkworms (1) (2). It is a proteolytic enzyme, which means it breaks down nonliving protein tissue into amino acids (1). Serrapeptase is most known for its anti-inflammatory and analgesic properties (1) (2).
Uses and Benefits
- Anti-inflammatory: Serrapeptase has anti-inflammatory properties and can help reduce swelling and inflammation (1) (2) (5).
- Pain relief: Serrapeptase has analgesic properties and can help reduce pain (1) (2).
- Mucolytic agent: Serrapeptase can act as a mucolytic agent, which means it can help thin mucus and make it easier to cough (4).
- Blood clot prevention: Serrapeptase may potentially help prevent blood clots (1) (5).
Dosage
The standard dose of serrapeptase is 10-60 mg per day (5). It is recommended to take serrapeptase on an empty stomach, at least one hour before eating or 2-3 hours after eating, to get the best results (1) (2). The maximum dose per day is not well established.
Serrapeptase dosage is usually given in SPU (serrapeptase units) or EU (enzymatic units) per milligram (mg) of serrapeptase. The conversion rate between SPU and mg is not standardized and can vary depending on the source and the method of measurement (2) (3) (5). However, as a general rule, the conversion is usually 2000 SPU/EU per mg (3) (5). Therefore, a dose of 10-60 mg of serrapeptase per day is equivalent to 20,000-120,000 SPU/EU per day (3) (5).
Serrapeptase is recommended to be taken on an empty stomach, at least one hour before eating or 2-3 hours after eating, to get the best results (1) (2). The maximum dose per day is not well established (5).
Side Effects
Serrapeptase is possibly safe when taken as medicine. Taking serrapeptase supplements for up to 4 weeks seems to be safe for adults (6). However, serrapeptase might interfere with blood clotting, so some researchers worry that it might make bleeding disorders worse (6). If you have a bleeding disorder, it is recommended to avoid taking serrapeptase (6).
Interactions
Serrapeptase may interact with blood-thinning medications, such as warfarin, heparin, aspirin, and clopidogrel, increasing the risk of bleeding (1) (2) (5). It is recommended to avoid taking serrapeptase with these medications.
Human Studies
Serrapeptase has been used routinely in medical practices in Asia and Europe for over 30 years (1). Although there are some clinical studies that suggest serrapeptase may be effective for reducing inflammation and swelling, the quality of the studies is generally poor, with inadequate control groups (5). More research is needed to determine the efficacy and safety of serrapeptase.
In conclusion, serrapeptase is an enzyme derived from silkworms. It is most known for its anti-inflammatory and analgesic properties. Serrapeptase may potentially help prevent blood clots and act as a mucolytic agent. The standard dose of serrapeptase is 10-60 mg per day, and it is recommended to take it on an empty stomach. Serrapeptase may interact with blood-thinning medications, and it is recommended to avoid taking it with these medications. Although there are some clinical studies that suggest serrapeptase may be effective for reducing inflammation and swelling, more research is needed to determine its efficacy and safety.
Citations:
(1) https://www.webmd.com/diet/health-benefits-serrapeptase
(2) https://www.verywellhealth.com/serrapeptase-89513
(3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585045/
(4) https://flo.health/health-articles/lifestyle/healthy-living/serrapeptase
(5) https://examine.com/supplements/serrapeptase/
(6) https://www.webmd.com/vitamins/ai/ingredientmono-1115/serrapeptase