R-Alfa Lipoic Acid
What is R-Lipoic Acid?
R-Lipoic acid is an endogenously synthesized antioxidant, found not only within the body but also in food sources such as red meat, carrots, beets, spinach, broccoli, and potatoes (1). Supplements also present an external source of R-Lipoic acid (1,3).
Uses and Benefits
- Antioxidant: R-Lipoic acid's antioxidative prowess offers protection against oxidative stress (1,3,6). This antioxidant facilitates the revival of other antioxidants, including vitamins C and E, and glutathione (1,3).
- Nerve pain: Diabetic individuals may find relief from nerve pain through R-Lipoic acid supplementation (1,3,6). This compound ameliorates symptoms such as pain, numbness, and burning sensations in the extremities (1,3).
- Other conditions: Other potential applications of R-Lipoic acid encompass conditions like hyperlipidemia, obesity, aging skin, and altitude sickness. However, robust scientific validation for these uses remains elusive (1,3).
Dosage
The standardized dosage for R-Lipoic acid is yet undefined. Nonetheless, research studies have predominantly utilized 300-600 mg per day (1,2). Adherence to labeled instructions on the supplement or seeking medical advice is recommended for tailored dosing.
Side Effects
R-Lipoic acid, when consumed as a dietary supplement, is largely deemed safe (1,3). A minority might encounter side effects such as dizziness, gastrointestinal discomfort, headaches, and mouth sores (1).
Interactions
There exists a potential for R-Lipoic acid to interact with antidiabetic drugs, like insulin and oral hypoglycemics, leading to heightened risks of hypoglycemia (1). Another interaction could occur with drugs reducing thyroid hormones, such as levothyroxine, possibly inducing hypothyroidism (1). Consulting a medical professional is essential before co-administration with other drugs or supplements.
Time of Day and With or Without Food
No specific time has been earmarked for R-Lipoic acid intake (1). Supplements of R-Lipoic acid, usually in capsule or soft gel forms, can be consumed with or without food (1,2).
Human Studies
R-Lipoic acid's antioxidative capabilities offer protection from oxidative damage and it also aids in alleviating diabetic nerve pain (1,3,6). However, comprehensive studies are yet awaited to shed light on the safety and efficacy of R-Lipoic acid across different conditions.
In summary, R-Lipoic acid is a natural antioxidant with potential benefits against oxidative stress and diabetic neuropathy. Although there's no standardized dosage, adhering to supplement labels or seeking professional guidance is prudent. Generally considered safe, R-Lipoic acid may present interactions, especially with antidiabetic and antithyroid medications. No particular time is suggested for its intake and it can be consumed with or without food. Further research will provide a clearer perspective on its therapeutic potential across a spectrum of health issues.
Citations:
(1) https://www.webmd.com/vitamins/ai/ingredientmono-767/alpha-lipoic-acid
(2) https://www.amazon.com/R-Alpha-Lipoic-R-LIPOIC-count-STRENGTH/dp/B01M0QS5C7
(3) https://www.mountsinai.org/health-library/supplement/alpha-lipoic-acid
(4) https://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid
(5) https://www.amazon.com/Stabilized-R-Alpha-Increased-Absorption-R-Lipoate/dp/B07DP8DHBH
(6) https://www.ncbi.nlm.nih.gov/books/NBK564301/