Quercetin
What is Quercetin?
Quercetin is a flavonol, which is part of the flavonoid group of polyphenols, known for their antioxidant properties that help scavenge harmful free radicals in the body (1) (2) (6). It's found in a variety of plant-based foods such as fruits, vegetables, grains, tea, and wine. The highest concentrations are seen in capers, red onions, kale, and berries (1) (2).
It is also a possible supplement known as "Senloytics"
Health Benefits of Quercetin:
- Antioxidant Power: Quercetin is valued for its ability to combat oxidative stress, which can lead to cellular and DNA damage (5) (6).
- Anti-inflammatory: It may inhibit inflammatory pathways by regulating substances like histamine, offering relief from allergies and asthma (2) (3) (5).
- Heart Health: There's potential for quercetin to protect against heart disease by improving blood vessel function and reducing inflammation and oxidative stress (2) (3) (5).
- Blood Pressure: Studies have suggested that it can help lower blood pressure levels (2) (5).
- Anti-cancer Potential: Lab research has shown quercetin exhibiting anticancer properties, but its effects in humans require more investigation (3).
- Allergy Symptom Relief: As a histamine stabilizer, it might ease symptoms related to allergies and hay fever (2).
- Prostate Health: There is preliminary evidence suggesting quercetin might reduce symptoms of prostatitis (2).
Forms and Combinations:
Quercetin is available in supplements, pills, and capsules, and is sometimes paired with bromelain for enhanced anti-inflammatory effects (2). Water-soluble forms like hesperidin-methyl-chalcone are also available.
Side Effects:
Quercetin is generally well-tolerated, but side effects can include headaches, tingling, and stomach upset (2). High doses might be harmful to the kidneys, so breaks from supplementation are recommended (2).
Interactions:
It may alter the metabolism of certain medications by the liver, particularly those processed by cytochrome P450 enzymes like CYP2D6 and CYP3A4 (3).
Dosage and Administration:
There is no standard dosage or optimal timing for taking quercetin, and whether it should be taken with food remains unspecified (1).
Human Studies and Efficacy:
While quercetin has been studied for a variety of health issues, strong scientific backing for most uses is still lacking (3) (5) (6). The majority of research has been in vitro or in animal models, necessitating more human studies to ascertain the benefits and safety of quercetin, especially in supplemental form over natural dietary intake (5) (6).