Nedocromil
What is Nedocromil?
Nedocromil is a medication classified as a mast cell stabilizer, which is used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma (4). It is available in two forms:
- Inhaler: Administered through an inhaler under the brand name Tilade.
- Eye drops: Used to treat itchy eyes due to allergies under the brand name Alocril (2)(4).
Nedocromil works by inhibiting the degranulation of mast cells, preventing the release of histamine and tryptase, and thus preventing the synthesis of prostaglandins and leukotrienes (4).
Side Effects
The common side effects of nedocromil include:
- Unpleasant taste in the mouth
- Cough
- Headache
- Nausea
- Stomach pain
- Sore throat
- Stuffy or runny nose
- Unusual tiredness or weakness
If these side effects persist or worsen, it is recommended to consult a doctor or pharmacist (6).
Interactions
Nedocromil may interact with the following medications:
- Acetazolamide: May increase the excretion rate of nedocromil, potentially reducing its efficacy.
- Acetylsalicylic acid: May decrease the excretion rate of nedocromil, potentially resulting in a higher serum level.
- Aclidinium: Nedocromil may decrease the excretion rate of aclidinium, potentially resulting in a higher serum level (3).
It is essential to inform your doctor or pharmacist about all the medications you are taking to avoid any potential interactions.
Time of Day and With or Without Food
The specific time of day to take nedocromil may vary depending on the individual and the form of the medication. It is best to follow the instructions provided by your doctor or pharmacist.
For eye drops, it is usually instilled twice daily (6).
Human Studies
Nedocromil has been well-studied in humans. It has been shown to be effective in alleviating symptoms of allergic conjunctivitis and has a significant inhibitory effect on allergen-induced early and late asthmatic reactions and on bronchial hyperresponsiveness (3)(4).
Citations:
(1) https://pubchem.ncbi.nlm.nih.gov/compound/Nedocromil
(2) https://www.webmd.com/drugs/2/drug-75042/nedocromil-ophthalmic-eye/details
(3) https://go.drugbank.com/drugs/DB00716
(4) https://en.wikipedia.org/wiki/Nedocromil
(5) https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/nedocromil
(6) https://medlineplus.gov/druginfo/meds/a601243.html