Methylprednisolone
What is Methylprednisolone?
Methylprednisolone is a synthetic glucocorticoid or corticosteroid medication that is used to treat a variety of conditions, including inflammation, severe allergies, asthma, arthritis, skin conditions, blood disorders, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis (3). It is available as a prescription drug and is not an over-the-counter supplement.
Time of Day and With or Without Food
The timing of methylprednisolone intake can vary depending on the condition being treated and the specific instructions from the healthcare provider. In some cases, it may be recommended to take the medication in the morning to mimic the body's natural cortisol production and minimize the risk of insomnia (3). However, it is essential to follow the prescribed dosing schedule and consult a healthcare professional for specific instructions.
Methylprednisolone can be taken with food or without food, depending on the individual's preference and tolerance. Taking the medication with food may help reduce stomach upset (3).
Dosage
The standard dose of methylprednisolone can vary depending on the condition being treated, the patient's age, weight, and overall health. It is essential to follow the prescribed dosing instructions provided by the healthcare provider. The maximum daily dose of methylprednisolone should not exceed 80 mg (3).
Side Effects
Common side effects of methylprednisolone can include:
- Stomach upset
- Headache
- Dizziness
- Menstrual period changes
- Trouble sleeping
- Increased sweating
- Acne
- Increased appetite
- Weight gain
More severe side effects can occur, such as:
- Vision problems
- Swelling
- Rapid weight gain
- Shortness of breath
- Severe depression
- Unusual thoughts or behavior
- Seizure (convulsions)
- Bloody or tarry stools, coughing up blood
- Pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate)
- Low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling)
If any of these side effects occur, it is essential to seek medical attention immediately (3).
Interactions
Methylprednisolone can interact with various medications and supplements, including:
- Mifepristone
- Dexamethasone
- DHEA
- Herbal products
- Nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, diflunisal, and ketorolac
- Calcium channel blockers such as diltiazem
- Anticoagulants or blood thinners such as warfarin
It is essential to inform the healthcare provider about all the medications and supplements being taken to avoid potential interactions (3).
Human Studies
Methylprednisolone has been extensively studied in humans, and its efficacy and safety have been established for various conditions. However, like any medication, it may not be suitable for everyone, and the benefits and risks should be carefully considered in each individual case.
Citations:
(1) https://www.fda.gov/media/71436/download
(2) https://www.webmd.com/drugs/2/drug-12114-1516/methylphenidate-hcl-oral/methylphenidate-extended-release-suspension-oral/details
(3) https://reference.medscape.com/drug/medrol-medrol-dosepak-methylprednisolone-342746
(4) https://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral/metformin-oral/details
(5) https://www.mayoclinic.org/drugs-supplements/metformin-oral-route/proper-use/drg-20067074
(6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/
Use of Methylprednisolone in MS
https://multiplesclerosisnewstoday.com/methylprednisolone/
Comparison Table of Corticosteroids
Below is a table that compares these corticosteroids based on relative potency, equivalent dose, and duration of action:
| Corticosteroid | Relative Potency | Equivalent Dose (mg) | Duration of Action |
|---|---|---|---|
| Hydrocortisone | 1 | 20 | Short |
| Prednisone | 4 | 5 | Intermediate |
| Prednisolone | 4 | 5 | Intermediate |
| Methylprednisolone | 5 | 4 | Intermediate |
| Triamcinolone | 5 | 4 | Intermediate |
| Deflazacort | 6 | 6 | Intermediate |
| Betamethasone | 25 | 0.75 | Long |
| Dexamethasone | 25 | 0.75 | Long |
Note: The potency and equivalent dose values in this table are approximate and can vary depending on the source. The duration of action can be affected by individual metabolism rates and formulations.