Methotrexate
What is Methotrexate?
Methotrexate is a medication available in oral, injectable, and intravenous forms. It is a prescription drug used to treat various conditions, including cancer, autoimmune diseases, and severe psoriasis. Methotrexate is classified as an antimetabolite and antifolate drug, working by inhibiting the growth of rapidly dividing cells in the body (1)(2)(4).
Dosage
Methotrexate dosage varies based on the condition being treated, patient's age, weight, and overall health. Typically taken once a week, doses can range from 5 mg to 30 mg. The maximum daily dose is 30 mg. Always take the medication as prescribed by a doctor, and never alter the dose or discontinue use without consulting them (1)(2)(4).
Side Effects
Methotrexate can lead to side effects like nausea, vomiting, diarrhea, mouth sores, hair loss, fatigue, and dizziness. Rare but severe side effects include liver damage, lung issues, and kidney damage. Regular monitoring by a physician is essential while on this medication. Should side effects arise, immediate consultation is advised (1)(2)(4).
Interactions
Methotrexate may interact with various medications and supplements, such as NSAIDs, aspirin, probenecid, sulfonamides, and penicillin. Always inform your physician of all medications and supplements you are on while prescribed methotrexate (1)(2)(4).
Time of Day and With or Without Food
Methotrexate is usually taken once a week. While it can be consumed with or without food, adhere to your doctor's specific instructions concerning its administration (1)(2)(4).
Human Studies
Methotrexate has been rigorously studied in humans, proving effective for multiple conditions, including cancer, autoimmune diseases, and severe psoriasis. However, due to potential side effects, continuous monitoring by a healthcare professional is essential (1)(2)(4).
In summary, Methotrexate is a prescription medication effective for treating various conditions. The dosage is condition-specific, and the drug may have multiple side effects. It can interact with numerous other medications, and its intake should always be under the strict supervision of a healthcare provider.
Citations:
(1) https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/description/drg-20084837
(2) https://www.ncbi.nlm.nih.gov/books/NBK556114/
(4) https://www.drugs.com/methotrexate.html