Lodoxamide
What is Lodoxamide?
Lodoxamide is an antiallergic medication primarily utilized for addressing certain ocular disorders attributable to allergies, such as vernal keratoconjunctivitis and vernal conjunctivitis (1) (2) (3) (4) (5) (6). It operates by targeting specific cells termed mast cells, inhibiting them from discharging substances that incite allergic reactions (4) (5). This drug is available as an ophthalmic solution for application directly into the eyes (2) (4) (5). Typically, Lodoxamide is administered four times daily. The period of treatment is largely dependent on the specific ailment, though it's often prescribed as a long-term solution (2) (4) (5).
Dosage
For addressing vernal keratoconjunctivitis and vernal conjunctivitis, the common Lodoxamide dosage is one to two drops in the impacted eye(s), administered four times daily for a duration of up to three months (2) (3) (4) (5) (6). The appropriate dosage can be influenced by factors such as age and weight (6). It's crucial to meticulously follow the directions provided on the prescription label. In case of any uncertainties, it's advisable to seek clarification from a doctor or pharmacist. Lodoxamide eye drops should be used strictly as prescribed (2) (4) (5).
Side Effects
Usage of Lodoxamide may lead to certain side effects. Common reactions associated with its ophthalmic use encompass symptoms like ocular irritation, burning sensations, stinging, itching, among others (2) (4) (5). Most of these side effects can be managed effectively. Notably, the incidence of these adverse events typically diminishes substantially after the first year of treatment (5).
Interactions
There's potential for Lodoxamide to interact with some medications. Therefore, it's prudent to consult a healthcare professional before integrating Lodoxamide with other drugs or supplements (2) (4) (5).
Summary:
Lodoxamide stands out as an antiallergic medication tailored for treating specific eye disorders stemming from allergies, like vernal keratoconjunctivitis and vernal conjunctivitis. Its mechanism of action is rooted in its ability to act on mast cells, preventing them from releasing allergy-inducing substances. Lodoxamide is dispensed as an ophthalmic solution for direct eye instillation. Generally, the dosage for treating the aforementioned conditions entails one to two drops in the affected eye(s), applied four times daily for up to three months. While Lodoxamide can lead to side effects such as eye irritation and itching, these typically decline after the initial year of therapy. There are potential interactions with other drugs, so consulting a medical expert before combining treatments is advisable.
Citations:
(1) https://en.wikipedia.org/wiki/Lodoxamide
(2) https://medlineplus.gov/druginfo/meds/a694014.html
(3) https://go.drugbank.com/drugs/DB06794
(4) https://www.mayoclinic.org/drugs-supplements/lodoxamide-ophthalmic-route/description/drg-20064541
(5) https://www.mayoclinic.org/drugs-supplements/lodoxamide-ophthalmic-route/precautions/drg-20064541?p=1
(6) https://reference.medscape.com/drug/alomide-lodoxamide-ophthalmic-999533