L-Tyrosine
What is L-Tyrosine?
L-Tyrosine stands as a pivotal amino acid that plays the role of a precursor in the biosynthesis of catecholamines such as dopamine (DA) and norepinephrine (NE) (2). Though classified as a nonessential amino acid, it has the unique capability to be synthesized from another amino acid termed phenylalanine (1).
Uses and Benefits
- Cognitive function: Supplementation of L-Tyrosine exhibits potential benefits in the cognitive domain, with enhancements observed in memory, attentiveness, and mental clarity (1,4,5). Its role in mitigating memory impairments under acute stress scenarios has been substantiated (2).
- Stress: L-Tyrosine manifests as an efficacious agent in alleviating stress-induced manifestations (4). Its consumption as a supplement is commonly practiced to replenish catecholamine reserves that get depleted under taxing conditions (2).
- Other conditions: L-Tyrosine has been explored for its therapeutic effects in conditions like depression, alcohol dependency, and multiple sclerosis. However, the empirical evidence backing these applications remains inchoate (2,5).
Dosage
The standardized dosage for L-Tyrosine remains undefined. Nonetheless, research-backed dosages span from 500-2000 mg daily (2). It is pivotal to adhere to the instructions specified on the supplement label or seek consultation with a medical professional for personalized dosage insights.
Side Effects
The safety profile of L-Tyrosine, when consumed as a dietary supplement, is generally commendable (1,4). Yet, a minority of individuals might encounter mild side effects such as vertigo, gastrointestinal discomforts, headaches, and oral sores (1).
Interactions
L-Tyrosine exhibits potential interactions, especially with antihypertensive drugs like ACE inhibitors and diuretics, heightening the risk of hypotension (1). It's imperative to consult healthcare experts before co-administering L-Tyrosine with other drugs or supplements.
Time of Day and With or Without Food
L-Tyrosine lacks a specific recommended timeframe for ingestion (1). Its supplements, commonly available in capsule or soft gel forms, can be consumed with or sans meals (1,6).
Human Studies
Empirical studies indicate the promise of L-Tyrosine in bolstering cognitive faculties, encompassing memory, attentiveness, and mental clarity, especially under acute stress scenarios (1,2,4,5). Comprehensive research initiatives are warranted to fully unravel its therapeutic potency and safety across myriad conditions.
In summation, L-Tyrosine, an amino acid precursor vital for the synthesis of catecholamines, showcases potential benefits in the cognitive realm and stress alleviation. Though its safety profile as a dietary supplement appears reassuring, potential drug interactions necessitate caution. With no specific timing recommendations for consumption, it can be ingested either with or without meals. Elaborate research endeavors remain essential to discern its comprehensive therapeutic and safety profile.
Citations:
(1) https://www.verywellhealth.com/everything-you-need-to-know-about-l-tyrosine-7567409
(2) https://examine.com/supplements/l-tyrosine/
(3) https://en.wikipedia.org/wiki/Tyrosine
(4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/
(5) https://www.mountsinai.org/health-library/supplement/tyrosine
(6) https://www.amazon.com/NOW-Supplements-L-Tyrosine-500-Capsules/dp/B0013OUPSE