Fisetin
What is Fisetin?
Fisetin is a flavonoid found in various fruits and vegetables like strawberries, apples, persimmons, grapes, onions, and cucumbers (2) (3) (6). This compound has demonstrated significant anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in both cell cultures and animal models pertinent to human illnesses (1) (2) (6). Furthermore, fisetin has been recognized as an influential senolytic drug, implying its ability to selectively remove senescent cells - aged cells that have ceased dividing and tend to accumulate as we age (1) (2) (4). Animal models have evidenced fisetin's potential to prolong health and lifespan in the context of aging and age-associated conditions (1) (2) (4). Other studies suggest its role in treating stroke (2) and its protective nature against cancer, diabetes, and obesity (2).
It is also a possible supplement known as "Senloytics"
Uses and Benefits
-
Anti-inflammatory: Fisetin's anti-inflammatory qualities can aid in decreasing inflammation (1) (2) (4) (5) (6).
-
Antioxidant: As a powerful antioxidant, Fisetin assists in safeguarding cells against oxidative stress (1) (2) (5) (6).
-
Anti-cancer: Fisetin displays anti-tumorigenic and anti-invasive effects in cell cultures and animal models (1) (2) (3) (6).
-
Neuroprotective: It has neuroprotective properties, potentially lowering the risk of neurodegenerative conditions (1) (2) (5) (6).
-
Cardiovascular health: Fisetin exhibits cardioprotective attributes, which might help diminish the risk of cardiovascular diseases (1) (2) (6).
Dosage
A standardized fisetin dosage has yet to be established. However, research has shown doses up to 1000 mg daily (1) (2) (4). It's advised to adhere to supplement label directions or seek counsel from a healthcare professional for individualized recommendations.
Side Effects
Generally deemed safe when consumed as a dietary supplement, excessive fisetin intake may be toxic, leading to liver damage (1) (3) (6). Moderation in fisetin consumption is paramount.
Interactions
Information regarding fisetin's interaction with other medicines or supplements is scarce. Prior to pairing fisetin with other medications or supplements, consulting with a healthcare provider is recommended.
Time of Day and With or Without Food
No particular time of day is recommended for fisetin consumption (2). Fisetin supplements, commonly in capsule or soft gel form, can be consumed with or devoid of food (1) (2).
Human Studies
While fisetin has shown potent effects in cell cultures and animal models concerning human diseases, the data on its impact on humans remains limited (1) (2) (6). Further studies are imperative to ascertain fisetin's efficacy and safety in humans.
In conclusion, fisetin, a flavonoid native to numerous fruits and vegetables, has manifested a plethora of benefits in cell cultures and animal models relevant to human ailments. It's identified as a senolytic drug, capable of removing senescent cells, and has demonstrated its potential to improve health and lifespan in aging-related conditions in animal models. While generally safe as a dietary supplement, excessive fisetin can be harmful. Its intake time is flexible and can be with or without meals. There's a paucity of information on fisetin's interactions with other drugs or supplements, and more research is vital to ascertain its effects and safety in humans.
Citations:
(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268460/
(2) https://www.sciencedirect.com/science/article/pii/B9780128229231000029
(3) https://www.science.gov/topicpages/n/natural+flavonoid+fisetin
(4) https://www.sciencedirect.com/science/article/pii/S2352396418303736
(5) https://www.sciencedirect.com/topics/neuroscience/fisetin
(6) https://scite.ai/reports/fisetin-and-its-role-in-NOvR49