Dihydroergotoxin
What is Dihydroergotoxin?
Dihydroergotoxin, is a semi-synthetic ergot alkaloid used to treat migraines and cluster headaches (1)(2). It is a derivative of ergotamine and is administered as a nasal spray or injection (2). Dihydroergotoxin works by binding to serotonin and adrenergic receptors, which helps to reduce the dilation of blood vessels in the brain that can cause migraines and headaches (2)(5).
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Therapeutic Action: Activator of metabolism and cerebral circulation. Stimulant of central neurotransmission. Peripheral vasodilator. Alpha-adrenergic blocker.
Indications
Indications: Adjunctive and symptomatic treatment of various intellectual dysfunctions, of the affective, somatic, and behavioral sphere typical of the decrease in cerebral performance due to neuronal, metabolic, or atherosclerotic origin. These dysfunctions may manifest as dizziness, difficulty in concentration, disorientation, memory disorder, decreased initiative, depressive mood, decreased sociability, as well as alterations in daily life activities and personal care.
Dosage
The dosage of dihydroergotoxin may vary depending on the individual's condition and response to treatment. It is usually administered as a nasal spray or injection, and the recommended dose may range from 0.5 to 1 mg per day (1)(3).
Dosage: 1.5 mg tablets: 1 tablet 3 times per day. 4.5 mg tablets: 1 tablet per day.
Other names
Dihydroergotoxine, tambiΓ©n conocida como ergoloid mesylates en EE.UU., co-dergocrine mesilate en Gran BretaΓ±a, o mesilato de dihidroergotoxina, se comercializa bajo el nombre de Hydergine. Es una mezcla de las sales de metanosulfonato de tres alcaloides de ergot dihidrogenados: dihidroergocristina, dihidroergocornina y alfa y beta dihidroergocriptina.
https://medlineplus.gov/druginfo/meds/a682097.html
https://www.drugs.com/mtm_esp/hydergine.html
Side Effects
Common side effects of dihyroergotoxin include nausea, vomiting, and dizziness. Rarely, it can cause more serious side effects, such as liver problems or an allergic reaction. If you experience any unusual symptoms while taking dihydroergotoxin, contact your healthcare provider immediately (1)(2)(3).
Interactions
Dihydroergotoxin may interact with other medications, including eletriptan, fluconazole, and St. John's Wort. Before taking dihydroergotoxin, tell your healthcare provider about all the medications and supplements you are taking (5).
Contraindications: Hypersensitivity to the drug. Acute and chronic psychosis, whatever its etiology. Vascular diseases (stroke, Raynaud's syndrome), temporal arteritis, coronary diseases (angina pectoris, asymptomatic ischemia), severe liver problems, and septicemia. Pregnancy and breastfeeding.
Health Benefits
Dihydroergotoxin is used to treat migraines and cluster headaches by reducing the dilation of blood vessels in the brain that can cause these conditions. By controlling blood vessel dilation, dihydroergotoxin may help to prevent or reduce the severity of migraines and headaches (1)(2).
note: althoug it is sometimes used for dementia. It did not help in alzheimer
https://www.nejm.org/doi/full/10.1056/nejm199008163230704
Recommended Time and Dosage
Dihydroergotoxin is usually administered as a nasal spray or injection, and the recommended dose may range from 0.5 to 1 mg per day. It is important to take dihidroergotoxina as prescribed by your healthcare provider to ensure the best possible outcome (1)(3).
Human Studies
Dihydroergotoxin has been studied extensively in clinical trials and has been shown to be effective in reducing the severity and frequency of migraines and cluster headaches. However, like all medications, dihydroergotoxin may not be suitable for everyone and may cause side effects in some people. It is important to talk to your healthcare provider about the risks and benefits of dihydroergotoxin before starting treatment (1)(2)(5).
Citations:
(1) https://www.sciencedirect.com/topics/medicine-and-dentistry/dihydroergotoxine
(2) https://en.wikipedia.org/wiki/Dihydroergotamine
(3) https://www.rxlist.com/dhe-45-drug.htm
(4) https://go.drugbank.com/drugs/DB00320
(5) https://reference.medscape.com/drug/dhe-45-dihydroergotamine-343028
(6) https://pubmed.ncbi.nlm.nih.gov/6285391/
https://www.sciencedirect.com/topics/medicine-and-dentistry/dihydroergotoxine
https://www.casasco.com.ar/es/producto/vimotadine/
where to buy:
https://www.farmalisto.com.mx/sistema-nervioso-central/10281-comprar-hydergina-15mg-con-24-Comprimidos-precio.html
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ΒΏCual es el sustituto de la Hydergina?
Diemil, Clinadil... etc pueden parecΓ©rsele, aunque no son exactamente lo mismo, porque el componente (Dihidroergotoxina) de la Hydergina ha sido eliminado del Vademecum
https://www.doctoralia.es/preguntas-respuestas/cual-es-el-sustituto-de-la-hydergina
parece que no era segura
https://farmacovigilancia.tv/blog/desde-hoy-no-se-puede-prescribir-ni-comercializar-hydergina/