Dehydroepiandrosterone (DHEA)
What is DHEA?
Dehydroepiandrosterone (DHEA) is a hormone naturally produced by the adrenal gland, playing a crucial role in producing other hormones like testosterone and estrogen (1) (2) (3) (4) (5) (6). Natural DHEA levels peak during early adulthood and decline with age (1). A synthetic form of DHEA is available in various forms such as tablets, capsules, powders, topical creams, and gels (1). People commonly use DHEA as an anti-aging therapy, for enhancing physical performance, and to alleviate depression and menopausal symptoms (1) (2) (3) (4) (5) (6).
Dosage
The recommended dosage of DHEA varies based on the targeted condition and the patient's weight (1) (2) (3) (4) (5) (6). Typically, DHEA dosages range from 25mg to 200mg per day when consumed orally (1) (2) (3). Treatment durations span from 6 to 12 months, contingent upon the condition (2).
Side Effects
While DHEA is generally well-tolerated, there are potential side effects. These might include acne, hair loss, stomach discomfort, headaches, and insomnia (1) (2) (3) (4) (5). Particularly at high doses, DHEA could lead to more severe complications like hypertension, heart palpitations, or liver damage (1) (2) (3) (4) (5).
Interactions
DHEA may have interactions with certain medications, notably insulin, corticosteroids, and other hormonal treatments (1) (3) (5). Before merging DHEA with other drugs or supplements, it's vital to consult a healthcare professional.
Human Studies
Research has probed into DHEA's potential health benefits, particularly its ability to improve physical performance, treat depression, and alleviate menopausal symptoms (1) (2) (3) (4) (5) (6). The outcomes, however, remain inconclusive, emphasizing the need for further studies to clarify its therapeutic efficacy.
In conclusion, DHEA is a hormone pivotal for generating other vital hormones, and its synthetic versions are accessible in multiple forms. Typical oral dosages lie between 25mg and 200mg daily. While DHEA is generally safe, there are potential side effects, and interactions with other medications necessitate medical guidance. Although DHEA has been explored for various health benefits, definitive evidence regarding its therapeutic impact remains elusive.
Citations:
(1) https://www.mayoclinic.org/drugs-supplements-dhea/art-20364199
(2) https://www.medicalnewstoday.com/articles/308684
(3) https://www.mountsinai.org/health-library/supplement/dehydroepiandrosterone
(4) https://www.webmd.com/vitamins/ai/ingredientmono-331/dhea
(5) https://www.webmd.com/diet/dhea-supplements
(6) https://www.verywellhealth.com/dhea-what-should-you-know-about-it-89136