CDP-Choline (Citicoline)
What is CDP-Choline (Citicoline)?
It is a supplement derived from Vitamin B4 (Choline)
CDP-Choline, colloquially known as Citicoline, is an intrinsic compound pivotal for the biosynthesis pathway of cell membrane structural phospholipids, predominantly Phosphatidylcholine (2)(5). As a nootropic entity, upon consumption, it metamorphoses into choline and cytidine, the latter subsequently transforming into uridine (5). Accessible as a dietary supplement, CDP-Choline is renowned for augmenting cognitive abilities, memory recall, and attention span (1)(3)(5)(6). Additionally, it plays a therapeutic role in the management of neurodegenerative afflictions such as Alzheimer's and Parkinson's, as well as in the recuperation from traumatic brain injuries (1)(2)(4).
Dosage
The recommended dosage of CDP-Choline is contingent upon the specific ailment in focus and the individual's weight (1). Typically, a daily intake of 250-500mg, bifurcated into two doses, is endorsed (5).
Side Effects
CDP-Choline is characterized by its commendable tolerability, with adverse manifestations being a rarity (1)(2)(4)(5). Some individuals, albeit a minority, may experience gastrointestinal disruptions, inclusive of abdominal discomfort, diarrhea, constipation, and cramps (2).
Interactions
The potential exists for CDP-Choline to exhibit interactions with specific pharmacological agents, notably anticoagulants and antiplatelet medications (1)(2)(4). As a prudent measure, those contemplating its simultaneous use with other drugs or supplements should seek expert medical counsel.
Time of Day and With or Without Food
CDP-Choline supplements exhibit flexibility in terms of consumption, being amenable to intake with or without food (1).
Human Studies
Extensive studies have been orchestrated to unravel the potential health dividends of CDP-Choline, notably its proficiency in elevating cognitive function, memory retention, and attentional focus (1)(2)(3)(5)(6). Additionally, its therapeutic potential in countering neurodegenerative diseases such as Alzheimer's and Parkinson's, and facilitating recovery post-traumatic brain injuries, has been a subject of investigation (1)(2)(4). Cumulatively, these studies corroborate the safety and high tolerability of CDP-Choline in human subjects (1)(2)(4)(5).
In essence, CDP-Choline, colloquially branded as Citicoline, is an innate compound imperative for the biosynthesis of phospholipids integral to cellular membranes. As a nootropic agent available as a dietary adjunct, it is acclaimed for its prowess in bolstering cognitive faculties, memory, and attention. Beyond its nootropic attributes, CDP-Choline has evoked interest for its therapeutic potential in neurodegenerative maladies and recuperative abilities post-brain trauma. While generally well-received, it is sagacious to remain cognizant of potential drug interactions and the standard dosage recommendations.
Citations:
(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683073/
(2) https://pubmed.ncbi.nlm.nih.gov/8709678/
(3) https://www.amazon.com/Choline-Citicoline-Supplement-Pharmaceutical-Capsules/dp/B01A3BED8U
(4) https://www.mhanational.org/cdp-choline
(5) https://examine.com/supplements/cdp-choline/
(6) https://www.amazon.com/Life-Extension-Cognizin-CDP-Choline-Vegetarian/dp/B000PC30Z0