Benfotiamine
What is Benfotiamine?
Benfotiamine is a synthetic, fat-soluble derivative of Vitamin B1 (Thiamine) (1). Specifically, it's an S-acyl derivative created in labs but it mirrors the activity of vitamin B1 within the body (6). Importantly, it boasts a higher bioavailability compared to traditional thiamine salts, leading to increased levels of thiamine in various organs, including the muscle, brain, liver, and kidney (1).
Clinical Studies
Benfotiamine is primarily utilized as an over-the-counter remedy for diabetic polyneuropathy (1). It has been the focus of several studies assessing its potential health benefits, ranging from cognitive improvements, kidney health, to anti-cancer properties (4). Notably, a 2021 review highlighted two clinical trials that demonstrated positive outcomes for diabetic polyneuropathy, but emphasized the need for further research (1).
Dosage
Depending on the specific ailment being treated and the weight of the patient, the dosage of benfotiamine can differ (1). Generally, an oral dosage of up to 600 mg daily, lasting for a period of up to 24 weeks, is considered standard (5).
Side Effects
In general, benfotiamine exhibits a good safety profile and adverse reactions are infrequent (5). That said, a small fraction of individuals have noted gastrointestinal disturbances, including feelings of nausea and abdominal discomfort (5).
Interactions
Benfotiamine, given its similarity to thiamine (vitamin B1) but superior absorption capabilities, can serve as an effective alternative (6). Nevertheless, it's crucial to engage in a consultation with a healthcare expert prior to mixing benfotiamine with other medications or supplements.
Time of Day and With or Without Food
Benfotiamine consumption offers flexibility, as it can be taken irrespective of meals (3).
In summary, benfotiamine is a lab-synthesized, fat-soluble variant of thiamine, characterized by its enhanced bioavailability. It's predominantly used for diabetic polyneuropathy. Various studies have probed its potential health advantages, such as cognitive enhancement, kidney health benefits, and even anti-cancer attributes. Typically, it's administered orally at doses up to 600 mg daily for a span of 24 weeks. Its side effects are generally minimal, though it's always wise to confer with a medical professional prior to its use, especially if being combined with other drugs. It can be ingested with or without food.
Citations:
(1) https://en.wikipedia.org/wiki/Benfotiamine
(2) https://www.verywellhealth.com/benfotiamine-89417
(3) https://www.amazon.com/Life-Extension-Benfotiamine-Thiamine-Vegetarian/dp/B000MYXVTQ
(4) https://www.news-medical.net/health/Benfotiamine-Health-Benefits-and-Side-Effects.aspx
(5) https://www.webmd.com/vitamins/ai/ingredientmono-1574/benfotiamine
(6) https://www.webmd.com/diabetes/benfotiamine-overview