Aripiprazole (Abilify)
What is Aripiprazole (Abilify)?
Aripiprazole, commercially known as Abilify and Aristada among other names, is an atypical antipsychotic drug primarily prescribed for conditions such as schizophrenia, bipolar I disorder, autism spectrum disorder, and Tourette disorder (2) (5) (6). It also finds use as a supplementary treatment in cases of major depressive disorder, tic disorders, and irritability stemming from autism (2). Aripiprazole functions by modulating dopamine and serotonin levels in the brain, both of which are vital neurotransmitters influencing mood, behavior, and cognition (5).
Dosage
The recommended dose of Aripiprazole depends on both the specific ailment being treated and the individual's weight (5) (6):
- For schizophrenia, the typical dose is between 10-15 mg daily, taken orally (5).
- For bipolar I disorder, 15 mg per day, taken orally, is standard (5).
- For major depressive disorder, dosages range from 2-15 mg daily, consumed orally (5).
Side Effects
Regular side effects accompanying Aripiprazole include symptoms like nausea, vomiting, constipation, diarrhea, dizziness, and dry mouth (1) (4) (5) (6). These are often mild and tend to subside in a short span. However, there are instances where Aripiprazole might lead to severe side effects, encompassing suicidal ideation, serotonin syndrome, and bleeding complications (1) (4) (5) (6).
Interactions
When combined with certain medications like carbamazepine, rifampin, and antihistamines, Aripiprazole might elicit enhanced side effects (5) (6). Before integrating Aripiprazole with other medicinal supplements, it's advisable to consult with a healthcare professional.
Time of Day and With or Without Food
Aripiprazole can be consumed irrespective of meal timings (5) (6).
Human Studies
Extensive human studies vouch for Aripiprazole's efficacy in addressing schizophrenia, bipolar I disorder, autism spectrum disorder, and Tourette disorder (2) (5) (6). It is predominantly well-received, with its side effects typically being transient and mild (1) (4) (5) (6).
In conclusion, Aripiprazole, recognized by brand names such as Abilify and Aristada, is an atypical antipsychotic medication employed to treat a range of conditions. The dosage is contingent on the condition and individual's weight. Comprehensive human studies endorse Aripiprazole's therapeutic potential. While its side effects are generally mild, certain drug interactions can enhance these effects.
Citations:
(1) https://www.abilify.com
(2) https://en.wikipedia.org/wiki/Aripiprazole
(3) https://www.webmd.com/drugs/2/drug-64439/abilify-oral/details
(4) https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Aripiprazole-(Abilify)
(5) https://my.clevelandclinic.org/health/drugs/19695-aripiprazole-tablets
(6) https://www.mayoclinic.org/drugs-supplements/aripiprazole-oral-route/side-effects/drg-20066890?p=1
Has Aripiprazole (Abilify) been used in low dose for ME/CFS?
Recent retrospective studies suggest that low dose Aripiprazole is safe and may be helpful in reducing fatigue and post-exertional malaise (PEM) in patients with ME/CFS (2). The study analyzed the symptoms of 101 patients before and after using a low dose of Aripiprazole, and about 75% of the patients reported experiencing less fatigue, brain fog, and PEM, and better sleep (2). The side effects were minimal, and the very low doses used in the study produced only mild side effects, such as headache, irritability/agitation, and extreme agitation (2).
However, since the trial was not placebo-controlled, it is unclear how effective Aripiprazole really is in treating ME/CFS (2). It is important to note that Aripiprazole is not licensed to treat ME/CFS, and it is an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar I disorder, autism spectrum disorder, and Tourette disorder (1)(5)(6). Aripiprazole can interact with other medications, including carbamazepine, rifampin, and antihistamines, which can increase the risk of side effects (5)(6). Prior consultation with a medical expert is recommended before using Aripiprazole for ME/CFS or combining it with other drugs or supplements.
Citations:
(1) https://meassociation.org.uk/2021/05/me-association-statement-aripiprazole-abilify-me-cfs/
(2) https://www.healthrising.org/blog/2021/03/09/abilify-chronic-fatigue-syndrome-promise/
(3) https://www.webmd.com/drugs/2/drug-64439/abilify-oral/details
(4) https://pubmed.ncbi.nlm.nih.gov/33536023/
(5) https://www.mayoclinic.org/drugs-supplements/aripiprazole-oral-route/side-effects/drg-20066890?p=1
(6) https://www.actionforme.org.uk/news/responding-to-questions-about-abilify/
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